MOSBIE

Rule-based modeling allows for the construction and simulation of models representing chemical interactions within and between cells. The iterative development of these models presents several challenges, including keeping track of the features encoded in each model and understanding the development history of the family of models.

In this work, we present the development and features of a journaling system to meet these challenges. A small multiples view displays the contact map rendering of each model in the development family. Users can interactively compare the similarities and differences between pairs of models, or search for models which contain an individual structure. A history tree view shows the development of the model family with respect to time.

More information about the project, as well as a download link, can be found at the official website.

Related Publications:

  • Journal: J. Wenskovitch, L. Harris, J.J. Tapia, J. Faeder, G.E. Marai. “MOSBIE: A Tool for Comparison and Analysis of Rule-Based Biochemical Models.” BMC Bioinformatics 2014 15:316.
  • Conference Poster: J. Wenskovitch, L. Harris, J. Faeder, G.E. Marai. “A Journaling System for Rule-Based Models.” IEEE BioVis Posters Compendium, 2013.

MOSBIE Model Browser